UpToDate

The future of healthcare starts with trust. We’re empowering clinicians and leaders to make confident decisions—faster than ever—while shaping a healthier tomorrow. Learn more about our vision for the #FutureOfHealthcare: https://ow.ly/gxYO50XyciW #HealthcareInnovation #ClinicalExcellence #HealthTech #UpToDate

In a multicenter trial of over 1000 nursing home residents ≥80 years of age (65 percent with moderate or severe frailty) who were taking at least two antihypertensive drugs and had a systolic blood pressure <130 mmHg, a strategy to de-intensify antihypertensive treatment resulted in similar rates of all-cause mortality and major adverse cardiovascular events as usual care at a median follow-up of 38 months. Deprescribing antihypertensives in frail older patients is likely safe. Stay #UpToDate with What’s New in #geriatrics: https://ow.ly/5A3O50X6um3 #ClinicalUpdates #MedEd

🧠 Yesterday’s #ClinicalChallenge was: True or false? A high percentage of patients with a distal biceps tendon rupture return to sport after surgical repair. 🎯The correct answer is: True. In a systematic review that included 42 studies and 1000 patients with distal biceps tendon rupture, 91 percent returned to sport after surgery. Most patients who returned attained preinjury levels of performance or higher. View the related What’s New topic in #UpToDate: https://ow.ly/INmc50XlZB5 #SportsMedicine #meded

🧠 True or false? A high percentage of patients with a distal biceps tendon rupture return to sport after surgical repair. #ClinicalChallenge #meded #SportsMedicine

The FDA approved updated labeling for Elevidys (delandistrogene moxeparvovec-rokl) following reports of fatal acute liver failure in nonambulatory patients. The revised labeling includes a Boxed Warning for serious liver injury, restricts use to ambulatory patients aged 4 years and older with confirmed DMD mutations, and removes the indication for nonambulatory patients. Additional updates include safety monitoring recommendations, contraindications, and a new Medication Guide. The manufacturer is also required to conduct a postmarketing study to further assess liver-related risks. Check out our drug referential resources: 💊https://ow.ly/vSrg50Xtv0E 💊https://ow.ly/b8Xo50Xtv0C #DrugNews #Pharmacy #Medication

Five generations are shaping healthcare, redefining how clinical information is accessed and shared. As Millennials and Gen Z take the lead, health leaders must adapt strategies to support diverse teams and empower patients with evidence-based care. Download the UpToDate Point of Care Report to learn more: https://ow.ly/KqzT50Xw64m #UpToDatePointOfCareReport #GenAIinHealthcare #MultigenerationalWorkforce #UpToDate

A meta-analysis of 84 observational studies found that antenatal and postnatal paternal mental distress (eg, depression, anxiety, stress) were associated with poorer global, social-emotional, cognitive, language, and physical development in offspring from birth to adolescence, with a stronger association with postnatal mental distress. These findings suggest that paternal mental health issues are a risk factor for adverse developmental outcomes in children. Stay #UpToDate with What’s New in #pediatrics: https://ow.ly/Y18A50X6ugZ #ClinicalUpdates #MedEd

In a randomized trial of over 140 patients with high-titer anti-cyclic citrullinated peptide antibodies (but without synovitis), treatment with hydroxychloroquine (HCQ) for one year did not impact the development of clinical rheumatoid arthritis (RA) after 36 months (30 versus 33 percent) compared with placebo. Rates of inflammatory arthritis, joint symptoms, and adverse events were also similar between groups. Alternative preventive strategies are needed to prevent progression to RA in high-risk individuals. Stay #UpToDate with What’s New in #primarycare: https://ow.ly/6vEI50X6ue3 #ClinicalUpdates #MedEd

Meet your patients where they are Digital tools and patient education can transform care delivery while reducing clinician burden. Providing flexible patient education options can enhance engagement across generations and help improve outcomes. Our expert, Amanda Heidemann shares her insights: https://ow.ly/st1s50Xw6ov #UpToDatePointOfCareReport #GenAIinHealthcare #MultigenerationalWorkforce #UpToDate

For over 30 years, clinicians around the world have trusted #UpToDate #clinicaldecisionsupport for the best available evidence for patient care. Find out why clinicians prefer #UpTodate: https://ow.ly/TABC50WanYF #UpToDateEnterpriseSuite #HealthcareInnovation #HealthTech