Alyssa Fronk presents AI-powered RNA splicing analysis at Bio-IT World

Exciting news in spatial biology! BioChain is proud to offer Xenium single-cell spatial transcriptomics services to help researchers unlock insights from FFPE and fresh tissue samples. A new Nature Communications study benchmarked Xenium against other platforms and showed: Consistent performance across tissue ages Accurate cell segmentation (Xenium-MM) Strong concordance with RNA-seq and immunoassays These results highlight Xenium’s power for oncology, biomarker discovery, and translational research — and we’re here to support your next study. 📖 Read the paper: Nature Communications

Spatial transcriptomics is changing how we see cancer biology, but to make such data clinically actionable, we need to go further. In a recent study led by Dr. poh sheng JOE YEONG’s lab at A*STAR - Agency for Science, Technology and Research, Singapore, researchers combined 10x Genomics Xenium and Lunaphore COMET data generated on the same tissue section to align same-cell RNA and protein expression with tumour pathology using Aspect Analytics Weave platform. They uncovered: ✅ Gene-to-protein expression at single-cell level ✅ Proteomic validation of transcriptomics data ✅ A unified and clinically relevant view of the biology of lung cancer Read the full success story on our blog: https://lnkd.in/eQGtB8yb #SpatialBiology 

🔬So insightful to read how the COMET instrument is revolutionizing the multiomics analysis of RNA and protein expression at a single-cell level in tumor pathology. Researchers uncovered gene-to-protein expression relationships, providing a unified and clinically relevant view of lung cancer biology. Feel free to get in touch if you want to discuss how this could be applied to your workflows. 🚀 Full story here: https://lnkd.in/dCr_EfF4 #spatialbiology #multiomics

🚨 Big news in methylation sequencing: The Illumina 5-base solution is officially here! While others are still stitching together multi-step workflows, Illumina is simplifying the game with: ✅ One workflow ✅ One readout ✅ Combined methylation and epigenomic insights No extra prep. No parallel pipelines. Just clean, streamlined data for researchers tackling rare disease, cancer, or developmental biology. And you get dual genomic + epigenomic annotations powered by DRAGEN™ analysis, with intuitive visualizations through Illumina Connected Multiomics. Curious how it stacks up against the competition? More here... https://bit.ly/48yi66m #Genomics #Epigenomics #Methylation #Illumina #5Base #NGS #Innovation #ASHG25

I had the opportunity to attend the Scotland Cancer Centre Inauguration Seminar hosted by Lunaphore (a Bio-Techne brand) in Glasgow. It was inspiring to see the launch of the COMET™ spatial biology platform, which enables high-plex, subcellular spatial profiling to uncover how cells interact within tumor tissues. As someone from a Biotechnology background, I was fascinated by how spatial multiomics is transforming our understanding of cancer. By mapping proteins and RNA within their native tissue environments, researchers can identify new biomarkers, understand tumor heterogeneity, and ultimately guide the development of more precise and effective therapies — improving outcomes for patients. Hearing from experts like Prof. Maria Libera Ascierto (PhD) and Prof. John Le Quesne on biomarker discovery and translational applications highlighted the exciting future of spatial multiomics in understanding tumor heterogeneity. Grateful to Lunaphore (a Bio-Techne brand), Prof. Maria Libera Ascierto (PhD) and the CRUK Scotland Institute for hosting such an insightful event highlighting how technology and research together can advance human health. #SpatialBiology #CancerResearch #MolecularBiology #TranslationalResearch #Biotech #LifeSciences #BiomedicalResearch #Lunaphore #CRUKScotland #Glasgow #ResearchCommunity #PrecisionMedicine #InnovationInHealthcare #ScientificInnovation 

🔬 New Blog Post: “Pathway Stories — How Cells Talk and Why It Matters” Every cell in our body is constantly sending and receiving tiny chemical messages. These molecular “conversations,” known as signaling pathways, control almost everything a cell does — from growth to repair to survival. When these pathways go wrong, the consequences can be serious — uncontrolled growth (as in cancer), faulty repair, or disrupted immune function. But by understanding how these messages are sent, received, and interpreted, we can start designing therapies that fix the signal, not just treat the symptom. In my latest blog post, I introduce the fascinating world of signaling pathways and explain why pathway analysis could be the key to the future of precision medicine. I also highlight one of the most studied examples — the Wnt/β-catenin pathway, crucial for development and stem cell renewal, yet deeply linked to cancer when misregulated. 👉 Read the full post here: https://lnkd.in/ey9hpfhs Let’s make molecular biology accessible — one pathway at a time. #MolecularBiology #PrecisionMedicine #BiomedicalResearch #ScienceCommunication #WntPathway #CancerResearch #PhDLife #ScienceBlog #CellSignaling #ResearchTranslation

A new study coming out of MD Anderson Cancer Center demonstrates how a multimodal imaging strategy can resolve critical questions about the biodistribution, stability, and clearance of liposomal carriers. By combining in vivo photoacoustic imaging with ex vivo cryo-fluorescence tomography, the team revealed how liposome-encapsulated J-aggregated indocyanine green (Lipo-JICG) undergoes breakdown and clearance over six days in murine models. This work underscores the value of CFT in mapping fluorescent payload release with high spatial resolution and full anatomical context, offering new insights for drug delivery and diagnostic carrier design. Read the full text: https://bit.ly/3Iv927E #DrugDelivery #CancerResearch #Biotech #PreclinicalResearch #ImagingScience #Liposomes #InVivoStudies #Research #MolecularBiology #BiomedicalResearch #TherapeuticResearch #Imaging

Imaging-based spatial transcriptomics (ST) is evolving as a pivotal technology in studying tumor biology and associated microenvironments. However, the strengths of the commercially available ST platforms in studying spatial biology have not been systematically evaluated using rigorously controlled experiments. We use serial 5 μm sections of formalin-fixed, paraffin-embedded surgically resected lung adenocarcinoma and pleural mesothelioma samples in tissue microarrays to compare the performance of the ST platforms (CosMx, MERFISH, and Xenium (uni/multi-modal)) in reference to bulk RNA sequencing, multiplex immunofluorescence, GeoMx, and hematoxylin and eosin staining data. In addition to an objective assessment of automatic cell segmentation and phenotyping, we perform a manual phenotyping evaluation to assess pathologically meaningful comparisons between ST platforms. Here, we show the intricate differences between the ST platforms, reveal the importance of parameters such as probe design in determining the data quality, and suggest reliable workflows for accurate spatial profiling and molecular discovery. Paper and research by Nejla Ozirmak Lermi, @Max Molina Ayala and larger team at MD Anderson Cancer Center. The excerpt above is from the author's manuscript.

🔬 Exploring the Power of Single Cell Omics From genomics to proteomics, traditional omics technologies have transformed the study of biology. Now, Single Cell Omics is taking research to the next level — enabling scientists to explore the complexity of individual cells within heterogeneous populations. AAT Bioquest's latest #catalog page highlights: 🧬 The significance of single cell omics 🧫 The general workflow of single-cell isolation ⚙️ The evolving applications driving breakthroughs in cancer, immunology, and precision medicine 👉 Explore how single cell omics is revolutionizing molecular biology — one cell at a time. https://lnkd.in/ghMUu_4x #Biotech #MolecularBiology #ResearchInnovation #Proteomics #Genomics

Exciting Update from CodeX! We’re thrilled to share that the Molecular Tumor Board (led by Bob Dolin)  and Pathogen Genomics (led by Emily Bordeleau) use cases are officially moving into the Planning stage of the CodeX Use Case Methodology. These use cases mark an important step in advancing interoperable standards to improve cancer care, precision medicine, and genomic data sharing across healthcare. Interested in getting involved? Reach out to us at 📩 pmo@hl7codex.org  — we’d love to hear from you! Elimu Informatics Simon Fraser University McMaster University #HL7 #FHIR #Interoperability #Genomics #Oncology #CodeX