Use this Python code:
import re
line = '<+play ing+> <+game s .+>'
line = re.sub(r'<\+\s*(.*?)\s*\+>', lambda z: z.group(1).replace(" ", ""), line)
print(line)
Results: playing games.
The lambda removes spaces additionally.
REGEX EXPLANATION
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< '<'
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\+ '+'
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\s* whitespace (\n, \r, \t, \f, and " ") (0 or
more times (matching the most amount
possible))
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( group and capture to \1:
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.*? any character except \n (0 or more times
(matching the least amount possible))
--------------------------------------------------------------------------------
) end of \1
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\s* whitespace (\n, \r, \t, \f, and " ") (0 or
more times (matching the most amount
possible))
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\+ '+'
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> '>'